Vitamins, cofactors and other substrates metabolism

Cryptosporidium muris

• CoA biosynthesis
• Lipoic acid incorporation
• NADP synthesis - NAD is salvaged from host and phosphorylated to NADP
• Pyridoxal phosphate (Vitamin B6) salvage
• Recycling of folate - Thymidylate synthase cycle
• Ubiquinone metabolism

Cryptosporidium parvum

• CoA biosynthesis
• Lipoic acid incorporation - Mitochondrial lipoic acid incorporation is absent. This is because no dehydrogenase enzyme complexes are present in C. parvum mitochondria.
• NADP synthesis - NAD is salvaged from host and phosphorylated to NADP
• Pyridoxal phosphate (Vitamin B6) salvage - The enzymes involved in pyridoxal phosphate metabolism in C. muris is missing in C. parvum. The examples of PLP dependent enzymes in C. parvum genome is present in the page: Pyridoxal phosphate dependent enzymes in C. parvum genome
• Recycling of folate - Thymidylate synthase cycle
• Ubiquinone metabolism

Cryptosporidium hominis

• CoA biosynthesis
• Lipoic acid incorporation - Mitochondrial lipoic acid incorporation is absent. This is because no dehydrogenase enzyme complexes are present in C. hominis mitochondria.
• NADP synthesis - NAD is salvaged from host and phosphorylated to NADP
• Pyridoxal phosphate (Vitamin B6) salvage - The enzymes involved in pyridoxal phosphate metabolism in C. muris is missing in C. hominis. The examples of PLP dependent enzymes in C. hominis genome is present in the page: Pyridoxal phosphate dependent enzymes in C. hominis genome
• Recycling of folate - Thymidylate synthase cycle
• Ubiquinone metabolism